Research projects financed by the National Science Center:
- OPUS: Cuproptosis, a novel pathway of regulated cell death as a therapeutic target in treatment-naïve and targeted therapy-resistant melanomas. Principal Investigator: Mariusz Hartman, (2024-2027);
- MINIATURA: Assessment of WNT/β-catenin pathway activity in vemurafenib- or trametinib- resistant melanoma cells. Principal Investigator: Anna Gajos-Michniewicz, (2021-2022);
- ETIUDA: The role of oxygen and insulin in the response of melanoma cells to targeted therapeutics in vitro. Principal Investigator: Marta Osrodek, (2020-2021);
- OPUS: Next generation in vitro experimental model of melanoma for pharmacological studies. Principal Investigator: Malgorzata Czyz, (2015-2018);
- SONATA: Inhibitors of anti-apoptotic proteins from the BCL-2 family as agents enhancing BRAFV600E inhibition in melanoma cells. Principal Investigator:Mariusz Hartman, (2017-2020);
- MINIATURA: Searching for an effective combination: parthenolide in combination with anticancer drugs from the NCI library. Principal Investigator: Malgorzata Sztiller-Sikorska, (2017-2018);
- PRELUDIUM: The role of insulin signaling in melanoma maintenance and response to targeted therapeutics. Principal Investigator: Marta Osrodek, (2017-2019);
- PRELUDIUM: Contribution of Bcl-2 proteins and melanocyte/melanoma-specific transcription factor MITF to melanoma cell survival under microenvironmental pressure. Principal Investigator: Mariusz Hartman, (2014-2016);
- HARMONIA: Identification of potential therapeutic targets in melanoma stem-like cells. (In collaboration with Institut de Cancérologie Gustave Rossy, France). Principal Investigator: Malgorzata Czyz, (2013-2015);
- OPUS: Characterization of melanospheres derived from clinical melanoma specimens in terms of their capability to recapitulate parental tumor phenotype, the frequency of cells with stem cell-like properties, and response to changes in microenvironment, including potential anticancer drugs. Principal Investigator: Malgorzata Czyz, (2012-2014);
- SONATA: The comparative analysis of miRNA expression profiles in melanospheres grown in embryonic stem cel medium and in melanoma cells stimulated with serum to grow in monolayer. Principal Investigator: Michał Wozniak, (2012-2014);
Other research projects:
- Project in collaboration with UAB Kelifarma (Lithuania): Development of a prototype of an advanced cell therapy medicinal product for the treatment of acute respiratory distress syndrome caused by the SARS-CoV-2 virus (KELI). Principal Investigator from Medical University of Lodz: Malgorzata Czyz, (2021-2022);